Normal movement selectivity in autism

Ilan Dinstein; Cibu Thomas; Kate Humphreys; Nancy Minshew; Marlene Behrmann; David J. Heeger

doi:10.1016/j.neuron.2010.03.034

Normal movement selectivity in autism

Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

It has been proposed that individuals with autism have difficulties understanding the goals and intentions of others because of a fundamental dysfunction in the mirror neuron system. Here, however, we show that individuals with autism exhibited not only normal fMRI responses in mirror system areas during observation and execution of hand movements but also exhibited typical movement-selective adaptation (repetition suppression) when observing or executing the same movement repeatedly. Movement selectivity is a defining characteristic of neurons involved in movement perception, including mirror neurons, and, as such, these findings argue against a mirror system dysfunction in autism. Video Abstract:

Original language	English
Pages (from-to)	461-469
Number of pages	9
Journal	Neuron
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2010.03.034
State	Published - 1 May 2010
Externally published	Yes

Keywords

HUMDISEASE
SYSNEURO

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2010.03.034

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title = "Normal movement selectivity in autism",

abstract = "It has been proposed that individuals with autism have difficulties understanding the goals and intentions of others because of a fundamental dysfunction in the mirror neuron system. Here, however, we show that individuals with autism exhibited not only normal fMRI responses in mirror system areas during observation and execution of hand movements but also exhibited typical movement-selective adaptation (repetition suppression) when observing or executing the same movement repeatedly. Movement selectivity is a defining characteristic of neurons involved in movement perception, including mirror neurons, and, as such, these findings argue against a mirror system dysfunction in autism. Video Abstract:",

keywords = "HUMDISEASE, SYSNEURO",

author = "Ilan Dinstein and Cibu Thomas and Kate Humphreys and Nancy Minshew and Marlene Behrmann and Heeger, {David J.}",

note = "Funding Information: Supported by National Institutes of Health Grants R01-MH069880 (D.J.H.), NICHD/NIDCD PO1/U19 (M.B.; PI: Nancy Minshew), F31-MH080457 (I.D.), Pennsylvania Department of Health grant SAP 4100047862, and Cure Autism Now (Young Investigator Award, K.H.). ",

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AU - Dinstein, Ilan

AU - Thomas, Cibu

AU - Humphreys, Kate

AU - Minshew, Nancy

AU - Behrmann, Marlene

AU - Heeger, David J.

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N2 - It has been proposed that individuals with autism have difficulties understanding the goals and intentions of others because of a fundamental dysfunction in the mirror neuron system. Here, however, we show that individuals with autism exhibited not only normal fMRI responses in mirror system areas during observation and execution of hand movements but also exhibited typical movement-selective adaptation (repetition suppression) when observing or executing the same movement repeatedly. Movement selectivity is a defining characteristic of neurons involved in movement perception, including mirror neurons, and, as such, these findings argue against a mirror system dysfunction in autism. Video Abstract:

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Normal movement selectivity in autism

Abstract

Keywords

ASJC Scopus subject areas

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