Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine

Petter I. Andersen; Klara Krpina; Aleksandr Ianevski; Nastassia Shtaida; Eunji Jo; Jaewon Yang; Sandra Koit; Tanel Tenson; Veijo Hukkanen; Marit W. Anthonsen; Magnar Bjoras; Magnus Evander; Marc P. Windisch; Eva Zusinaite; Denis E. Kainov

doi:10.3390/v11100964

Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine

Petter I. Andersen, Klara Krpina, Aleksandr Ianevski, Nastassia Shtaida, Eunji Jo, Jaewon Yang, Sandra Koit, Tanel Tenson, Veijo Hukkanen, Marit W. Anthonsen, Magnar Bjoras, Magnus Evander, Marc P. Windisch, Eva Zusinaite, Denis E. Kainov

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Viruses are the major causes of acute and chronic infectious diseases in the world. According to theWorld Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.

Original language	English
Article number	964
Journal	Viruses
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/v11100964
State	Published - 18 Oct 2019
Externally published	Yes

Keywords

Antiviral agent
Broad-spectrum antiviral
Drug target
Systems biology
Virus

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v11100964

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title = "Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine",

abstract = "Viruses are the major causes of acute and chronic infectious diseases in the world. According to theWorld Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.",

keywords = "Antiviral agent, Broad-spectrum antiviral, Drug target, Systems biology, Virus",

author = "Andersen, {Petter I.} and Klara Krpina and Aleksandr Ianevski and Nastassia Shtaida and Eunji Jo and Jaewon Yang and Sandra Koit and Tanel Tenson and Veijo Hukkanen and Anthonsen, {Marit W.} and Magnar Bjoras and Magnus Evander and Windisch, {Marc P.} and Eva Zusinaite and Kainov, {Denis E.}",

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year = "2019",

month = oct,

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doi = "10.3390/v11100964",

language = "English",

volume = "11",

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AU - Andersen, Petter I.

AU - Krpina, Klara

AU - Ianevski, Aleksandr

AU - Shtaida, Nastassia

AU - Jo, Eunji

AU - Yang, Jaewon

AU - Koit, Sandra

AU - Tenson, Tanel

AU - Hukkanen, Veijo

AU - Anthonsen, Marit W.

AU - Bjoras, Magnar

AU - Evander, Magnus

AU - Windisch, Marc P.

AU - Zusinaite, Eva

AU - Kainov, Denis E.

PY - 2019/10/18

Y1 - 2019/10/18

N2 - Viruses are the major causes of acute and chronic infectious diseases in the world. According to theWorld Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.

AB - Viruses are the major causes of acute and chronic infectious diseases in the world. According to theWorld Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.

KW - Antiviral agent

KW - Broad-spectrum antiviral

KW - Drug target

KW - Systems biology

KW - Virus

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Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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