Novel gastroretentive dosage forms: Evaluation of gastroretentivity and its effect on riboflavin absorption in dogs

Eytan A. Klausner, Eran Lavy, David Stepensky, Michael Friedman, Amnon Hoffman

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Purpose. The purpose of this study was to design novel gastroretentive dosage forms (GRDFs) based on unfolding multilayer polymeric films, to investigate the mechanism of their gastroretentivity in dogs, and to assess the effect of compounding a narrow absorption window drug in a GRDF on the drug's absorption properties. Methods. Dosage forms (DFs) with different dimensions and mechanical properties were administered to beagle dogs with acidic buffer (pH = 1.5), whose gastric retention time (GRT) was then determined by X-ray pictures. Concurrent administration of radiopaque markers was used to assess the effect of the GRDF and/or acidic buffer on GRT. The absorption of riboflavin from a prototype GRDF was compared with a nongastroretentive controlled-release DF and to an oral solution of the drug. Results. Large DFs (≥2.5 × 2.5 cm) containing rigid frame had prolonged GRT (>4 h). Administration of 400 mL of acidic buffer (or water) prolonged GRT whereas the GRDF did not cause additional prolongation. The extended absorption phase (>48 h) of riboflavin administered in a GRDF led to 4-fold increased bioavailability. Conclusion. The combination of large dimensions with rigidity produce gastroretentivity that can be used to improve absorption properties of a model of narrow absorption window drugs in the gastro-intestinal tract.

Original languageEnglish
Pages (from-to)1516-1523
Number of pages8
JournalPharmaceutical Research
Issue number10
StatePublished - 1 Oct 2002
Externally publishedYes


  • Controlled release
  • Dogs
  • Drug delivery
  • Gastroretentive
  • Intestinal absorption
  • Riboflavin

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


Dive into the research topics of 'Novel gastroretentive dosage forms: Evaluation of gastroretentivity and its effect on riboflavin absorption in dogs'. Together they form a unique fingerprint.

Cite this