Novel hybrid esterase-haloacid dehalogenase enzyme

Ana Beloqui, Julio Polaina, José María Vieites, Dolores Reyes-Duarte, Rodrigo Torres, Olga V. Golyshina, Tatyana N. Chernikova, Agnes Waliczek, Amir Aharoni, Michail M. Yakimov, Kenneth N. Timmis, Peter N. Golyshin, Manuel Ferrer

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


(Figure Presented) Promiscuous proteins: The identification and characterization of a wild-type promiscuous hydrolase that efficiently catalyzes the hydrolysis of ester bonds and haloacids in a single protein has been reported. This study has demonstrated the utility of metagenomics to access novel catalytic activities.

Original languageEnglish
Pages (from-to)1975-1978
Number of pages4
Issue number14
StatePublished - 24 Sep 2010


  • Dehalogenases
  • Esterases
  • Hydrolysis
  • Metagenomes
  • Protein design

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry


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