Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction

Natalie Landa; Micha S. Feinberg; Radka Holbova; Liron Miller; Smadar Cohen; Jonathan Leor

doi:10.1016/j.yjmcc.2006.03.230

Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction

Natalie Landa
, Micha S. Feinberg
, Radka Holbova
, Liron Miller
, Smadar Cohen
, Jonathan Leor

Department of Biotechnology Engineering

Research output: Contribution to journal › Meeting Abstract

Abstract

Cessation or reversal of progressive left ventricular (LV) dysfunction is a major aim of heart failure therapy. We developed a cross-linked concentrated alginate solution, which upon solidification in tissue becomes a hydrogel. The aim of the present study was to test the hypothesis that an injection of this novel alginate solution mimicking the extracellular matrix (ECM) into an old scar tissue, late after myocardial infarction (MI), will provide physical and biological scaffolding, will promote tissue rejuvenation and will prevent progressive LV dysfunctio

Original language	English
Pages (from-to)	998-998
Number of pages	1
Journal	Journal of Molecular and Cellular Cardiology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.yjmcc.2006.03.230
State	Published - Jun 2006

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10.1016/j.yjmcc.2006.03.230

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title = "Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction",

abstract = "Cessation or reversal of progressive left ventricular (LV) dysfunction is a major aim of heart failure therapy. We developed a cross-linked concentrated alginate solution, which upon solidification in tissue becomes a hydrogel. The aim of the present study was to test the hypothesis that an injection of this novel alginate solution mimicking the extracellular matrix (ECM) into an old scar tissue, late after myocardial infarction (MI), will provide physical and biological scaffolding, will promote tissue rejuvenation and will prevent progressive LV dysfunctio",

author = "Natalie Landa and Feinberg, \{Micha S.\} and Radka Holbova and Liron Miller and Smadar Cohen and Jonathan Leor",

year = "2006",

month = jun,

doi = "10.1016/j.yjmcc.2006.03.230",

language = "English",

volume = "40",

pages = "998--998",

journal = "Journal of Molecular and Cellular Cardiology",

issn = "0022-2828",

publisher = "Academic Press",

number = "6",

}

Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction. / Landa, Natalie; Feinberg, Micha S.; Holbova, Radka et al.
In: Journal of Molecular and Cellular Cardiology, Vol. 40, No. 6, 06.2006, p. 998-998.

Research output: Contribution to journal › Meeting Abstract

TY - JOUR

T1 - Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction

AU - Landa, Natalie

AU - Feinberg, Micha S.

AU - Holbova, Radka

AU - Miller, Liron

AU - Cohen, Smadar

AU - Leor, Jonathan

PY - 2006/6

Y1 - 2006/6

N2 - Cessation or reversal of progressive left ventricular (LV) dysfunction is a major aim of heart failure therapy. We developed a cross-linked concentrated alginate solution, which upon solidification in tissue becomes a hydrogel. The aim of the present study was to test the hypothesis that an injection of this novel alginate solution mimicking the extracellular matrix (ECM) into an old scar tissue, late after myocardial infarction (MI), will provide physical and biological scaffolding, will promote tissue rejuvenation and will prevent progressive LV dysfunctio

AB - Cessation or reversal of progressive left ventricular (LV) dysfunction is a major aim of heart failure therapy. We developed a cross-linked concentrated alginate solution, which upon solidification in tissue becomes a hydrogel. The aim of the present study was to test the hypothesis that an injection of this novel alginate solution mimicking the extracellular matrix (ECM) into an old scar tissue, late after myocardial infarction (MI), will provide physical and biological scaffolding, will promote tissue rejuvenation and will prevent progressive LV dysfunctio

U2 - 10.1016/j.yjmcc.2006.03.230

DO - 10.1016/j.yjmcc.2006.03.230

M3 - Meeting Abstract

SN - 0022-2828

VL - 40

SP - 998

EP - 998

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

IS - 6

ER -

Novel injectable alginate scaffold attenuates progressive infarct expansion and preserves left ventricular systolic and diastolic function late after myocardial infarction

Abstract

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