Abstract
In this report, we present a novel spectroscopic method of follow-up during chemotherapy treatment for B- and T-cell childhood leukemia patients. We isolated peripheral lymphocytes from blood drawn from patients before and after the chemotherapy and collected Microscopic FTIR (FTIR-MC) spectra of the isolated lymphocytes. Our results showed that nucleic acids content decreased in both types of patients. Changes in phospholipids and proteins level could be observed. The overall effects of drugs administered to the patients can be understood at the molecular level using FTIR-MC and these results are expected to stimulate wider applications of spectroscopy in leukemia research.
| Original language | English |
|---|---|
| Pages (from-to) | 251-261 |
| Number of pages | 11 |
| Journal | Journal of Biochemical and Biophysical Methods |
| Volume | 51 |
| Issue number | 3 |
| DOIs | |
| State | Published - 31 May 2002 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Acute lymphoblastic leukemia
- Drugs
- FTIR microspectroscopy
- Follow-up
- Lymphocytes
ASJC Scopus subject areas
- Biophysics
- Biochemistry
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