Novel pharmacological approaches for treatment of obstructive sleep apnea in children

Leila Kheirandish-Gozal, Jinkwan Kim, Aviv D. Goldbart, David Gozal

    Research output: Contribution to journalReview articlepeer-review

    25 Scopus citations

    Abstract

    Introduction: The lymphadenoid tissues in the upper airway are sparse and organized lympho-epithelial structures playing an important role against foreign pathogens, with the palatine tonsils being the major components of the lymphoid tissues contained in the Waldeyer's ring. Obstructive sleep apnea (OSA) has emerged as a very frequent condition in the pediatric age range that is associated with substantial neurobehavioral, cardiovascular and metabolic morbidities. Adenotonsillar hypertrophy is the major pathophysiological contributor to OSA occurrence in children. Areas covered: Here, the authors provide a systematic review and summary of some of the known histological and pathological features of human lymphadenoid tissues and their fundamental immunological functions, provide insights into the pathophysiology of pediatric OSA, particularly focusing on inflammatory pathways and the available outcomes associated with targeting such pathways with compounds such as corticosteroids and leukotriene modifiers. Furthermore, they present findings from an unbiased approach to discovery of therapeutic targets and formulate constructs toward putative future interventional approaches for this highly prevalent condition. Expert opinion: Surgical approaches for pediatric OSA may not be as effective as previously anticipated. Accordingly, expanded use of existing systemic or topical anti-inflammatory agents or development of novel compounds targeting selected immune cell populations underlying pathophysiological determinants of OSA is needed.

    Original languageEnglish
    Pages (from-to)71-85
    Number of pages15
    JournalExpert Opinion on Investigational Drugs
    Volume22
    Issue number1
    DOIs
    StatePublished - 1 Jan 2013

    Keywords

    • Adenotonsillar hypertrophy
    • Adenotonsillectomy
    • Costicosteroids
    • Inflammation
    • Leukotrienes
    • Obstructive sleep apnea
    • Tonsils
    • Transcriptome
    • Upper airway

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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