Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

Varda Shoshan-Barmatz; Arie Lev Gruzman

Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

Varda Shoshan-Barmatz (Inventor), Arie Lev Gruzman (Inventor)

Department of Life Sciences

Research output: Patent

Abstract

Abstract Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

Original language	English
Patent number	AU2021200421
IPC	C07D 403/ 04 A I
Priority date	22/01/21
State	Published - 25 Feb 2021

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title = "Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction",

abstract = "Abstract Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.",

author = "Varda Shoshan-Barmatz and {Lev Gruzman}, Arie",

year = "2021",

month = feb,

day = "25",

language = "English",

type = "Patent",

note = "AU2021200421; C07D 403/ 04 A I",

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TY - PAT

T1 - Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

AU - Shoshan-Barmatz, Varda

AU - Lev Gruzman, Arie

PY - 2021/2/25

Y1 - 2021/2/25

N2 - Abstract Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

AB - Abstract Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

M3 - Patent

M1 - AU2021200421

ER -

Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

Abstract

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