NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION

Varda Shoshan-Barmatz (Inventor), Arie Lev Gruzman (Inventor)

Research output: Patent

Abstract

Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.

Original languageEnglish
Patent numberUS2021040047
IPCC07D 491/ 04 A I
Priority date6/08/20
StatePublished - 11 Feb 2021

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