NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION

Varda Shoshan-Barmatz (Inventor), Arie Lev Gruzman (Inventor)

Research output: Patent

Abstract

Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.
Original languageEnglish
Patent numberHK1257495
IPCA61P C I
Priority date13/09/16
StatePublished - 25 Oct 2019

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