NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION

Varda Shoshan-Barmatz (Inventor), Arie Lev Gruzman (Inventor), Varda Shoshan-Barmatz (Inventor), Arie Lev Gruzman (Inventor)

Research output: Patent

Abstract

Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

Original languageEnglish
Patent numberUS2018118700
IPCC07D 211/ 66 A I
Priority date13/09/16
StatePublished - 3 May 2018

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