Novel spectral method for the study of viral carcinogenesis in vitro

Mahmoud Huleihel, Ahmad Salman, Vitaly Erukhimovitch, Jagannathan Ramesh, Ziad Hammody, Shaul Mordechai

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Fourier transform infrared (FTIR) spectroscopy is a unique technique for the laboratory diagnosis of cellular variations based on the characteristic molecular vibrational spectra of the cells. Microscopic FTIR was used to investigate spectral differences between normal and malignant fibroblasts transformed by retrovirus infection. A detailed analysis showed significant differences between cancerous and normal cells. The contents of vital cellular metabolites were significantly lower in the transformed cells than in the normal cells. In an attempt to identify the cellular components responsible for the observed spectral differences between normal and cancerous cells, we found significant differences between DNA of normal and cancerous cells.

Original languageEnglish
Pages (from-to)111-121
Number of pages11
JournalJournal of Biochemical and Biophysical Methods
Issue number2-3
StatePublished - 4 Jan 2002


  • Cancer
  • Diagnosis
  • FTIR microscopy
  • IR spectroscopy
  • Malignant cells
  • NIH/3T3 cells
  • Retroviruses

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry


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