Novel therapeutic strategies against cytomegalovirus infection

B. Ranger-Zisman, A. Palmon, S. Blagerman, S. Tel-Or, D. Benharroch, M. Pecht, N. Trainin, Y. Burstein

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    Murine CMV (MCMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV (HCMV) infection. MCMV causes T cell immune impairment in the infected mice, manifested by suppressed responses to T cell mitogens and a profound reduction of Con A induced IL-2 production. Thymic humoral factor (THF-γ2) is an octapeptide which was first isolated from calf thymus, characterized and chemically synthesized. This peptide has been shown to have immunoregulatory effects in various systems. Systemic treatment of MCMV-infected mice with THF-γ2 resulted in the enhancement of protective efficacy of MCMV immune spleen cells and the reconstitution of mitogenic responses and IL-2 secretion.

    Original languageEnglish
    Pages (from-to)250-261
    Number of pages12
    JournalNatural Immunity
    Issue number5-6
    StatePublished - 1 Dec 1995


    • Adoptive transfers
    • Immunotherapy
    • Interleukin-2
    • Mitogenic responses
    • Murine cytomegalovirus
    • Thymic humoral factor

    ASJC Scopus subject areas

    • Immunology


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