Novel thieno[2,3-d]pyrimidines: Their design, synthesis, crystal structure analysis and pharmacological evaluation

Keyphrases

• Pyrimidine 100%
• Pharmacological Evaluation 100%
• Crystal Structure Analysis 100%
• Phosphodiesterase-4 (PDE4) 100%
• Inhibitory Properties 50%
• Dose Effect 25%
• Cyclization 25%
• Potential Inhibitors 25%
• Cyclohexanone 25%
• Sequence of Steps 25%
• Molecular Arrangement 25%
• Six-membered 25%
• Nitriles 25%
• Benzylic 25%
• Heterocyclic Rings 25%
• Fused Heterocycles 25%
• Ring-fused 25%
• Five-membered Heterocycles 25%
• Heterocyclic Moiety 25%
• Cyclohexane Ring 25%
• Hydrogen Bonding Pattern 25%
• Expeditious Synthesis 25%
• Thienopyrimidine 25%
• Pyrimidine Derivatives 25%
• Pattern Arrangement 25%
• Gewald Reaction 25%
• Krapcho Decarboxylation 25%

Chemistry

• % Inhibition 100%
• Crystal Structure 100%
• Heterocyclic Compound 100%
• Primary Structure 50%
• Decarboxylation 50%
• Hydrogen Bonding 50%
• Cyclohexanone 50%
• Nitrile 50%
• Cyclohexane Ring 50%
• Gewald Synthesis 50%
• Dieckmann Condensation 50%

Pharmacology, Toxicology and Pharmaceutical Science

• thieno[2,3 D]pyrimidine Derivative 100%
• Tumor Necrosis Factor 33%
• Nitrile 33%
• Cyclohexane 33%
• Cyclohexanone 33%
• Fused Heterocyclic Rings 33%