Nuclear track-based biosensing: an overview

Dietmar Fink, Gerardo Muñoz Hernández, Humberto García Arellano, Jiri Vacík, Vladimir Havranek, Vladimir Hnatowicz, Arik Kiv, Lital Alfonta

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


An overview on the development of biosensors based on nuclear tracks in solids is presented. A few decades ago it was found that nuclear tracks in solids can be usefully applied for the creation of biosensors. Meanwhile quite a number of different strategies have emerged to fulfill this task which are summarized here. We ourselves have especially concentrated on the ‘Product Enrichment Strategy’, where the enrichment of products of a given analyte by a suitable biochemical reaction within the narrow confinement of etched ion tracks is used to amplify the product’s signal for high-sensitivity biosensing. We also report on the application of nuclear analysis techniques for obtaining a deeper insight into these sensor structures, for the sake of their further optimization. Last not least we also discuss competing nanopore-based biosensing approaches.

Original languageEnglish
Pages (from-to)173-185
Number of pages13
JournalRadiation Effects and Defects in Solids
Issue number1-2
StatePublished - 1 Feb 2016


  • Swift heavy ions
  • biosensors
  • biotechnology
  • enzymes
  • etching
  • ion tracks
  • irradiation
  • nanopores
  • polymers

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Materials Science (all)
  • Condensed Matter Physics


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