Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli

Anteneh H. Abebe; Itay Gelber; Alex Aranovich; Mario Feingold; Itzhak Fishov

doi:10.1016/j.bpj.2017.11.1839

Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli

Anteneh H. Abebe, Itay Gelber, Alex Aranovich, Mario Feingold, Itzhak Fishov

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Segregation of the replicating chromosome from a single to two nucleoid bodies is one of the major processes in growing bacterial cells. It is tightly correlated with cell growth and division and this correlation is crucial for cell viability. The mechanism of segregation is still enigmatic: although it is believed that the underlying driving force is purely thermodynamic, it is obvious that the segregation dynamics is tuned by intricate interactions with other cellular processes. These interactions serve for flexibility in a changing environment and may possibly be the source of cell-to-cell phenotypic variability. We exploited the advantage of the chromosomally encoded HU-eGFP to monitor nucleoid segregation in live E. coli cells using time-lapse microscopy [from the article]

Original language	English
Pages (from-to)	328A
Number of pages	1
Journal	Biophysical Journal
Volume	114
Issue number	3
DOIs	https://doi.org/10.1016/j.bpj.2017.11.1839
State	Published - Feb 2018

Access to Document

10.1016/j.bpj.2017.11.1839

Cite this

@article{43846f81f0f04476ba1ace32bf4fd299,

title = "Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli",

abstract = "Segregation of the replicating chromosome from a single to two nucleoid bodies is one of the major processes in growing bacterial cells. It is tightly correlated with cell growth and division and this correlation is crucial for cell viability. The mechanism of segregation is still enigmatic: although it is believed that the underlying driving force is purely thermodynamic, it is obvious that the segregation dynamics is tuned by intricate interactions with other cellular processes. These interactions serve for flexibility in a changing environment and may possibly be the source of cell-to-cell phenotypic variability. We exploited the advantage of the chromosomally encoded HU-eGFP to monitor nucleoid segregation in live E. coli cells using time-lapse microscopy [from the article]",

author = "Abebe, {Anteneh H.} and Itay Gelber and Alex Aranovich and Mario Feingold and Itzhak Fishov",

year = "2018",

month = feb,

doi = "10.1016/j.bpj.2017.11.1839",

language = "English",

volume = "114",

pages = "328A",

journal = "Biophysical Journal",

issn = "0006-3495",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli

AU - Abebe, Anteneh H.

AU - Gelber, Itay

AU - Aranovich, Alex

AU - Feingold, Mario

AU - Fishov, Itzhak

PY - 2018/2

Y1 - 2018/2

N2 - Segregation of the replicating chromosome from a single to two nucleoid bodies is one of the major processes in growing bacterial cells. It is tightly correlated with cell growth and division and this correlation is crucial for cell viability. The mechanism of segregation is still enigmatic: although it is believed that the underlying driving force is purely thermodynamic, it is obvious that the segregation dynamics is tuned by intricate interactions with other cellular processes. These interactions serve for flexibility in a changing environment and may possibly be the source of cell-to-cell phenotypic variability. We exploited the advantage of the chromosomally encoded HU-eGFP to monitor nucleoid segregation in live E. coli cells using time-lapse microscopy [from the article]

AB - Segregation of the replicating chromosome from a single to two nucleoid bodies is one of the major processes in growing bacterial cells. It is tightly correlated with cell growth and division and this correlation is crucial for cell viability. The mechanism of segregation is still enigmatic: although it is believed that the underlying driving force is purely thermodynamic, it is obvious that the segregation dynamics is tuned by intricate interactions with other cellular processes. These interactions serve for flexibility in a changing environment and may possibly be the source of cell-to-cell phenotypic variability. We exploited the advantage of the chromosomally encoded HU-eGFP to monitor nucleoid segregation in live E. coli cells using time-lapse microscopy [from the article]

U2 - 10.1016/j.bpj.2017.11.1839

DO - 10.1016/j.bpj.2017.11.1839

M3 - Meeting Abstract

SN - 0006-3495

VL - 114

SP - 328A

JO - Biophysical Journal

JF - Biophysical Journal

IS - 3

ER -

Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli

Abstract

Access to Document

Fingerprint

Cite this