Nucleus-targeted drug delivery: Theoretical optimization of nanoparticles decoration for enhanced intracellular active transport

Ohad Cohen, Rony Granek

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A rational design for a nanoparticle is suggested, which will maximize its arrival efficiency from the plasma membrane to the nuclear surrounding. The design is based on grafting the particle surface with polymer spacers, each ending with a motor protein associating molecule, for example, nuclear localization signal peptide. It is theoretically shown that the spacer polymer molecular weight can be adjusted to significantly increase the effective particle processivity time. This should lead to appreciable enhancement of active transport of the nanocarrier, and consequently drug delivery, to the nucleus.

Original languageEnglish
Pages (from-to)2515-2521
Number of pages7
JournalNano Letters
Volume14
Issue number5
DOIs
StatePublished - 14 May 2014

Keywords

  • Drug delivery
  • active transport
  • intracellular transport
  • nanocarriers
  • nanoparticles
  • processivity time

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics
  • Mechanical Engineering

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