Dynamic tests of three reinforced concrete samples and six Dynablok samples were performed in the blast simulator facility at the University of California San-Diego (UCSD). The purpose of these tests was to evaluate the performance of a novel protective wall design. These tests were numerically simulated at the Protective Technologies Research and Development Center (PTR&DC) of the Ben-Gurion University (BGU) in Beer-Sheva, Israel. The simulations were carried out using two commercial hydro-codes: LS-Dyna and Dytran. The purpose of these simulations was to calibrate the parameters of the material models available in the above codes. Once calibrated, the simulation results showed good agreement with the test results for largely deflected yet moderately damaged specimens.