NUMT (new mighty) hypothesis of longevity

Khachik K. Muradian, Gilad Lehmann, Vadim E. Fraifeld

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Maximum life span (MLS) and abundance of mitochondrial DNA (mtDNA) insertions in the nuclear DNA (NUMTs) were analyzed in 17 animal species with completely sequenced mitochondrial and nuclear genomes. Highly significant positive correlations were found between MLS and NUMT number, total size, or density (both in mammals and all animal species). In mammals, NUMT abundance correlated positively with the mtDNA guanine content and negatively with adenine and thymine contents, but did not correlate with such longevity-associated variables as the body mass and resting metabolic rate.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalRejuvenation Research
Volume13
Issue number2-3
DOIs
StatePublished - 1 Apr 2010

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