Abstract
Obesity is a complex multifactorial condition that often manifests in early life with a lifelong burden on metabolic health. Diet, including pre-pregnancy maternal diet, in utero nutrition and dietary patterns in early and late life, can shape obesity development. Growing evidence suggests that epigenetic modifications, specifically DNA methylation, might mediate or accompany these effects across life stages and generations. By reviewing human observational and intervention studies conducted over the past 10 years, this work provides a comprehensive overview of the evidence linking nutrition to DNA methylation and its association with obesity across different age periods, spanning from preconception to adulthood and identify future research directions in the field.
| Original language | English |
|---|---|
| Pages (from-to) | 991-1015 |
| Number of pages | 25 |
| Journal | Epigenomics |
| Volume | 15 |
| Issue number | 19 |
| DOIs | |
| State | Published - 1 Oct 2023 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- age acceleration
- bioactive components
- childhood obesity
- diet
- epigenetic signatures
- macronutrients
- maternal nutrition
- methylation age
- minerals
- overweight or obesity
- vitamins
ASJC Scopus subject areas
- Genetics
- Cancer Research
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