Observations and Modeling of Synchronized Bursting in Two-Dimensional Neural Networks

R. Segev, Y. Shapira, M. Benveniste, E. Ben-Jacob

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


We present long-term (Formula presented) measurements of the spontaneous activity of two-dimensional cortical cell neural networks placed on multielectrode arrays. We compare histograms of single neuron interspike intervals and the network intersynchronized bursting events intervals. In addition, the effect of Ca concentration on the network activity is being studied. At 1 mM Ca concentration, the network exhibits periodic synchronized bursting that fades away after about 20 min. We present a feedback-regulated integrate and fire model to account for the observations. In the model we include two additional features: dynamical threshold and synapse fatigue.

Original languageEnglish
Article number011920
Number of pages9
JournalPhysical Review E
Issue number1
StatePublished - 27 Jun 2001
Externally publishedYes

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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