Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task

Oren Kaplan; Reuven Dar; Lirona Rosenthal; Haggai Hermesh; Mendel Fux; R. E. Lubow

doi:10.1016/j.brat.2005.09.005

Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task

Oren Kaplan, Reuven Dar, Lirona Rosenthal, Haggai Hermesh, Mendel Fux, R. E. Lubow

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.

Original language	English
Pages (from-to)	1137-1145
Number of pages	9
Journal	Behaviour Research and Therapy
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/j.brat.2005.09.005
State	Published - 1 Aug 2006
Externally published	Yes

Keywords

Anxiety
Attention
Latent inhibition
Obsessive-compulsive disorder (OCD)
Schizophrenia
Visual search

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Clinical Psychology
Psychiatry and Mental health

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10.1016/j.brat.2005.09.005

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title = "Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task",

abstract = "Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.",

keywords = "Anxiety, Attention, Latent inhibition, Obsessive-compulsive disorder (OCD), Schizophrenia, Visual search",

author = "Oren Kaplan and Reuven Dar and Lirona Rosenthal and Haggai Hermesh and Mendel Fux and Lubow, {R. E.}",

note = "Funding Information: The writing of this paper was supported by a grant from The Israel Science Foundation funded by the Israel Academy of Sciences and Humanities. ",

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doi = "10.1016/j.brat.2005.09.005",

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AU - Kaplan, Oren

AU - Dar, Reuven

AU - Rosenthal, Lirona

AU - Hermesh, Haggai

AU - Fux, Mendel

AU - Lubow, R. E.

N1 - Funding Information: The writing of this paper was supported by a grant from The Israel Science Foundation funded by the Israel Academy of Sciences and Humanities.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.

AB - Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.

KW - Anxiety

KW - Attention

KW - Latent inhibition

KW - Obsessive-compulsive disorder (OCD)

KW - Schizophrenia

KW - Visual search

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ER -

Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task

Abstract

Keywords

ASJC Scopus subject areas

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