Obstetric outcome of twin pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously

Yael Adler-Levy, Eitan Lunenfeld, Amalia Levy

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Objective: To compare the obstetric characteristics of twin pregnancies conceived by in vitro fertilization (IVF) and ovulation induction with those conceived spontaneously. Design: Case control study. Setting: Tertiary Medical Center. Patients: All twin deliveries that were achieved by IVF (n = 558) and ovulation induction (n = 478) from January 1988 through December 2002 were evaluated. Each group was compared with a control group that conceived spontaneously (n = 3694) and was delivered during the same period. Interventions: Ovulation induction, IVF-ET. Main outcome measures: Obstetrical complications. Results: Multivariate analysis showed that patients who conceived with the assistance of IVF and ovulation induction had a significantly higher risk for gestational diabetes mellitus (odds ratio [OR] = 2.41, 95% confidence interval [CI] = 1.77-3.29 and OR = 1.71, CI = 1.2-2.42, respectively), cesarean section (OR = 2.17, 95% CI = 1.74-2.70 and OR = 1.76, CI = 1.43-2.16, respectively), and a lower gestational age at birth in the IVF group (OR = 0.91, 95% CI = 0.88-0.94), compared with their controls. Conclusions: After controlling for maternal age, and nulliparity we demonstrated that twin pregnancies conceived with the assistance of IVF and ovulation induction are at increased risk for gestational diabetes mellitus, and delivery by cesarean section. In addition, IVF conceived pregnancies have a lower gestational age at birth.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volume133
Issue number2
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Gestational diabetes mellitus
  • In vitro fertilization
  • Neonatal complications
  • Obstetric complications
  • Ovulation induction
  • Twins

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