Oesophageal eosinophilia in children with coeliac disease

Anne Ari, Sara Morgenstern, Gabriel Chodick, Manar Matar, Ari Silbermintz, Amit Assa, Yael Mozer-Glassberg, Firas Rinawi, Vered Nachmias-Friedler, Raanan Shamir, Noam Zevit

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objectives An association between coeliac disease (CD) and eosinophilic oesophagitis (EoE)/oesophageal eosinophilia (EE) has been suggested. We sought to characterise children with CD+EE in-depth and assess the contribution of each condition to the clinical presentation and treatment response. Study design Medical records of children with both CD+EE, or isolated EoE diagnosed between 2000 and 2014, were retrospectively reviewed and compared with patients with isolated CD or epigastric pain. Frequency of EE was calculated from endoscopy results of patients with suspected CD or epigastric pain between 2011 and 2014. Missing data were obtained via a telephone questionnaire. Setting Single large, tertiary paediatric centre. Patients 17 CD+EE, 46 EoE, 302 isolated CD and 247 epigastric pain. Results The patients with CD+EE shared characteristics of both individual conditions. While age at diagnosis, family history of autoimmunity/CD and anaemia were similar to patients with CD, other characteristics such as male gender, personal/family history of atopy, peripheral eosinophilia and oesophageal white papules were more similar to patients with EoE. Combined patients (CD+EE) tended to present with CD-associated symptoms; the majority (63%) later developed typical EoE symptoms. Only a minority (21%) of combined patients had EE that resolved after a gluten-free diet; another 21% had normalisation of EE upon proton pump inhibitor treatment. The remainder required EoE-specific treatment. Conclusion Patients with CD found to have EE share characteristics with both isolated CD and EoE. It appears that these are two coexisting entities presenting in the same patient rather than eosinophilia associated with CD, and therefore, interventions separately addressing each condition may be considered.

Original languageEnglish
Pages (from-to)825-829
Number of pages5
JournalArchives of Disease in Childhood
Issue number9
StatePublished - 1 Sep 2017
Externally publishedYes


  • Coeliac disease
  • Eosinophilic oesophagitis
  • celiac disease
  • eosinophilic esophagitis
  • esophageal eosinophilia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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