TY - JOUR
T1 - Offspring of parents with schizophrenia
T2 - Mental disorders during childhood and adolescence
AU - Hans, Sydney L.
AU - Auerbach, Judith G.
AU - Styr, Benedict
AU - Marcus, Joseph
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Although offspring of parents with schizophrenia are at risk for schizophrenic illness as adults, little is known about their pattern of symptoms as children and adolescents. Lifetime Axis I and II DSM-III-R diagnoses were made for 116 young people (ages 12-22). Forty-one subjects had a parent with schizophrenia, 39 had a parent with a nonschizophrenic mental disorder, and 36 had parents with no mental illness. Schizophrenia spectrum disorders occurred at higher rates among young people with a parent with schizophrenia (17.1%) than in other young people (5.3%), even after controlling for mental disorder in the nonproband parent. Schizophrenia and schizotypal personality disorder occurred exclusively in offspring of parents with schizophrenia. Offspring of parents with schizophrenia were also at increased risk for avoidant personality disorder but not paranoid personality disorder. Although lifetime anxiety disorders were common in all young people regardless of parent diagnosis, current anxiety disorders were more prevalent for the adolescent offspring of parents with schizophrenia. These data strongly suggest familial vulnerability to schizophrenia spectrum disorder that is observable before adulthood, particularly for males.
AB - Although offspring of parents with schizophrenia are at risk for schizophrenic illness as adults, little is known about their pattern of symptoms as children and adolescents. Lifetime Axis I and II DSM-III-R diagnoses were made for 116 young people (ages 12-22). Forty-one subjects had a parent with schizophrenia, 39 had a parent with a nonschizophrenic mental disorder, and 36 had parents with no mental illness. Schizophrenia spectrum disorders occurred at higher rates among young people with a parent with schizophrenia (17.1%) than in other young people (5.3%), even after controlling for mental disorder in the nonproband parent. Schizophrenia and schizotypal personality disorder occurred exclusively in offspring of parents with schizophrenia. Offspring of parents with schizophrenia were also at increased risk for avoidant personality disorder but not paranoid personality disorder. Although lifetime anxiety disorders were common in all young people regardless of parent diagnosis, current anxiety disorders were more prevalent for the adolescent offspring of parents with schizophrenia. These data strongly suggest familial vulnerability to schizophrenia spectrum disorder that is observable before adulthood, particularly for males.
KW - Avoidant personality
KW - High risk
KW - Schizophrenia
KW - Schizophrenia spectrum
UR - http://www.scopus.com/inward/record.url?scp=3042664377&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.schbul.a007080
DO - 10.1093/oxfordjournals.schbul.a007080
M3 - Article
C2 - 15279048
AN - SCOPUS:3042664377
SN - 0586-7614
VL - 30
SP - 303
EP - 315
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 2
ER -