Olanzapine treatment after clozapine induced agranulocytosis

P. Lokshin, P. Dorfman, D. Shoshani, P. Wimmer, M. Dossenbach, R. H. Belmaker

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    Clozapine is an atypical antipsychotic with a significant incidence of agranulocytosis. Olanzapine resembles clozapine structurally; however, it lacks a halogen, which has been implicated in agranulocytosis. Both agents have a similar pharmacological profile. We therefore studied olanzapine in patients with a history of clozapine-induced agranulocytosis. Two patients with severe clozapine-induced agranulocytosis and no benefit from classic neuroleptics were treated with olanzapine with informed consent. Psychosis improved in both patients and no hematological changes were noted. Olanzapine may be a safe treatment alternative in patients with a history of clozapine agranulocytosis.

    Original languageEnglish
    Pages (from-to)583-584
    Number of pages2
    JournalHuman Psychopharmacology
    Volume13
    Issue number8
    DOIs
    StatePublished - 1 Dec 1998

    Keywords

    • Agranulocytosis
    • Clozapine
    • Olanzapine

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