Abstract
Clozapine is an atypical antipsychotic with a significant incidence of agranulocytosis. Olanzapine resembles clozapine structurally; however, it lacks a halogen, which has been implicated in agranulocytosis. Both agents have a similar pharmacological profile. We therefore studied olanzapine in patients with a history of clozapine-induced agranulocytosis. Two patients with severe clozapine-induced agranulocytosis and no benefit from classic neuroleptics were treated with olanzapine with informed consent. Psychosis improved in both patients and no hematological changes were noted. Olanzapine may be a safe treatment alternative in patients with a history of clozapine agranulocytosis.
Original language | English |
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Pages (from-to) | 583-584 |
Number of pages | 2 |
Journal | Human Psychopharmacology |
Volume | 13 |
Issue number | 8 |
DOIs | |
State | Published - 1 Dec 1998 |
Keywords
- Agranulocytosis
- Clozapine
- Olanzapine
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Pharmacology (medical)