Oligoclonality of moloney leukemias

Rivka Ofir, Jacob Gopas, Esther Aflalo, Yacob Weinstein

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Induction of leukemia by non-transforming retroviruses results in the appearance of various hematopoietic tumors. It is believed that these tumors are monoclonal. In this work, the clonal nature of Moloney leukemia virus (MoLV)-induced tumors was studied. Two genetic parameters were used in order to identify leukemic clones: the pattern of the proviral integration sites and the rearrangement of the T-cell receptor complex (TCR). In more than 60% of the mice, different leukemic clones populated tumors developed in different organs of the same animal. Genotypic analysis of cell lines derived from a leukemic organ revealed that the tumor is composed of more than one clone. Phenotypic analysis of subclones which were derived from a monoclonal cell line showed variability in the expression of the Thy 1.2 and MHC antigens. The results indicate that MoLV-induced tumors are of oligoclonal nature. Each leukemic organ contains a mixture of leukemic clones, of which one is dominant.

Original languageEnglish
Pages (from-to)797-806
Number of pages10
JournalLeukemia Research
Volume16
Issue number8
DOIs
StatePublished - 1 Jan 1992

Keywords

  • MoLV
  • leukemic cells
  • lymphokines
  • rearrangement

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