Oligodeoxynucleotide analogs with 5′-linked anthraquinone

Kenya Mori; Chrisanthi Subasinghe; Jack S. Cohen

doi:10.1016/0014-5793(89)80626-X

Oligodeoxynucleotide analogs with 5′-linked anthraquinone

Kenya Mori, Chrisanthi Subasinghe, Jack S. Cohen

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

We report here the synthesis of novel 5′-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).

Original language	English
Pages (from-to)	213-218
Number of pages	6
Journal	FEBS Letters
Volume	249
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80626-X
State	Published - 5 Jun 1989
Externally published	Yes

Keywords

Anthraquinone, 5′-linked
Nuclease resistance
Oligodeoxynucleotide, antisense

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(89)80626-X

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title = "Oligodeoxynucleotide analogs with 5′-linked anthraquinone",

abstract = "We report here the synthesis of novel 5′-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).",

keywords = "Anthraquinone, 5′-linked, Nuclease resistance, Oligodeoxynucleotide, antisense",

author = "Kenya Mori and Chrisanthi Subasinghe and Cohen, {Jack S.}",

year = "1989",

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T1 - Oligodeoxynucleotide analogs with 5′-linked anthraquinone

AU - Mori, Kenya

AU - Subasinghe, Chrisanthi

AU - Cohen, Jack S.

PY - 1989/6/5

Y1 - 1989/6/5

N2 - We report here the synthesis of novel 5′-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).

AB - We report here the synthesis of novel 5′-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).

KW - Anthraquinone, 5′-linked

KW - Nuclease resistance

KW - Oligodeoxynucleotide, antisense

UR - http://www.scopus.com/inward/record.url?scp=0024329933&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(89)80626-X

DO - 10.1016/0014-5793(89)80626-X

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JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Oligodeoxynucleotide analogs with 5′-linked anthraquinone

Abstract

Keywords

ASJC Scopus subject areas

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