On membrane potential and ciliary stimulation

M. Bar-Shimon, A. Tarasiuk, Y. Grossman, Z. Priel

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


The relation between membrane potential and ciliary beat frequency was examined in tissue cultures from frog palate and esophagus. It was found that hyperpolarization or depolarization of the ciliary cell membrane enhances ciliary beating. The induced enhancement of the ciliary beat frequency by either hyperpolarization or depolarization depends on the extracellular Ca2+ concentration, however, the involvement of voltage-gated calcium channels is unlikely, since blockers of voltage-gated channels at their specific concentrations did not have any effect. However, partial inhibition was achieved by a 10-50 fold increase in the concentration of blockers. Moreover, it was shown that the magnitude of ciliary activation depends on the method by which depolarization of the cell was achieved. Quinidine (1 mM) abolished ciliary enhancement induced by either hyperpolarization or depolarization. Based on these findings we conclude that the enhancement of ciliary beating is not controlled solely by the membrane potential.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalBioelectrochemistry and Bioenergetics
Issue number2
StatePublished - 1 May 1997
EventProceedings of the 1996 13th International Symposium on Bioelectrochemistry and Bioenergetics - Ein Gedi, Isr
Duration: 7 Jan 199612 Jan 1996


  • Ciliary beating
  • Membrane potential

ASJC Scopus subject areas

  • Biophysics
  • Physical and Theoretical Chemistry
  • Electrochemistry


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