On the efficiency of water soluble antioxidants

Paz Elia, Amnon Azoulay, Yehuda Zeiri

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The wide use of high intensity ultrasound (HIU) in modern medicine raises the question of bio-safety. It has been shown that the effect of HIU in biological media may have similarity to the effects of ionizing radiation. Exposure of biological media to HIU field may lead to cavitation phenomenon followed by formation of free radicals such as hydroxyl radical (OH ·) and the super-oxide ion (O2·-) . These are highly reactive species that may cause harmful effects and induce oxidative stress. In the present study we employed electron spin resonance (ESR) spectroscopy together with spin traps to quantify the dynamics of hydroxyl radical formation during exposure to HIU field in the presence of different amounts of six antioxidants. Thus, the efficiency of water-soluble antioxidants, namely Allicin, Melatonin, Deoxyribose, Trolox, Nuphlutine and Hermidin, to suppress accumulation of OH radicals was examined. The results show that among the six, Trolox and Allicin reduce hydroxyl concentration with the highest efficiency.

Original languageEnglish
Pages (from-to)314-324
Number of pages11
JournalUltrasonics Sonochemistry
Issue number2
StatePublished - 1 Jan 2012


  • Antioxidants
  • EPR
  • ESR
  • Efficiency of antioxidants
  • Electronic structure

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Environmental Chemistry
  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics
  • Organic Chemistry
  • Inorganic Chemistry


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