On the reaction mechanism of MoS42- with nitric oxide

Inna Popivker; Israel Zilbermann; Eric Maimon; Dror Shamir; Naomi Meyerstein; Dan Meyerstein

doi:10.1016/j.inoche.2010.02.010

On the reaction mechanism of MoS₄^2- with nitric oxide

Inna Popivker, Israel Zilbermann, Eric Maimon, Dror Shamir, Naomi Meyerstein, Dan Meyerstein

Research output: Contribution to journal › Article › peer-review

Abstract

MoS₄^2- (TTM) reacts in deaerated neutral phosphate buffered aqueous solutions with NO. Three consecutive reactions are observed. The two first ones obey pseudo first order rate laws with observed rates proportional to [NO]. The third reaction obeys a first order rate law. Nitrite is one of the final products. The mechanism proposed involves thiol nitrosation via a radical mechanism followed by hydrolysis of the S-N bond. The findings indicate that if MoS₄^2- will be used as a drug, it will not affect considerably the NO concentration in the system.

Original language	English
Pages (from-to)	589-592
Number of pages	4
Journal	Inorganic Chemistry Communications
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/j.inoche.2010.02.010
State	Published - 1 May 2010

Keywords

Drug
NO
Nitrosation
Radical mechanism
Tetrathiomolybdate

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.inoche.2010.02.010

Cite this

@article{0199fbd084a54f49ae1ac1671752b8b2,

title = "On the reaction mechanism of MoS42- with nitric oxide",

abstract = "MoS42- (TTM) reacts in deaerated neutral phosphate buffered aqueous solutions with NO. Three consecutive reactions are observed. The two first ones obey pseudo first order rate laws with observed rates proportional to [NO]. The third reaction obeys a first order rate law. Nitrite is one of the final products. The mechanism proposed involves thiol nitrosation via a radical mechanism followed by hydrolysis of the S-N bond. The findings indicate that if MoS42- will be used as a drug, it will not affect considerably the NO concentration in the system.",

keywords = "Drug, NO, Nitrosation, Radical mechanism, Tetrathiomolybdate",

author = "Inna Popivker and Israel Zilbermann and Eric Maimon and Dror Shamir and Naomi Meyerstein and Dan Meyerstein",

note = "Funding Information: This study was supported in part by a grant from the Budgeting and Planning Committee of The Council of Higher Education and the Israel Atomic Energy Commission . D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.",

year = "2010",

month = may,

day = "1",

doi = "10.1016/j.inoche.2010.02.010",

language = "English",

volume = "13",

pages = "589--592",

journal = "Inorganic Chemistry Communications",

issn = "1387-7003",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - On the reaction mechanism of MoS42- with nitric oxide

AU - Popivker, Inna

AU - Zilbermann, Israel

AU - Maimon, Eric

AU - Shamir, Dror

AU - Meyerstein, Naomi

AU - Meyerstein, Dan

N1 - Funding Information: This study was supported in part by a grant from the Budgeting and Planning Committee of The Council of Higher Education and the Israel Atomic Energy Commission . D.M. wishes to express his thanks to Mrs. Irene Evens for her ongoing interest and support.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - MoS42- (TTM) reacts in deaerated neutral phosphate buffered aqueous solutions with NO. Three consecutive reactions are observed. The two first ones obey pseudo first order rate laws with observed rates proportional to [NO]. The third reaction obeys a first order rate law. Nitrite is one of the final products. The mechanism proposed involves thiol nitrosation via a radical mechanism followed by hydrolysis of the S-N bond. The findings indicate that if MoS42- will be used as a drug, it will not affect considerably the NO concentration in the system.

AB - MoS42- (TTM) reacts in deaerated neutral phosphate buffered aqueous solutions with NO. Three consecutive reactions are observed. The two first ones obey pseudo first order rate laws with observed rates proportional to [NO]. The third reaction obeys a first order rate law. Nitrite is one of the final products. The mechanism proposed involves thiol nitrosation via a radical mechanism followed by hydrolysis of the S-N bond. The findings indicate that if MoS42- will be used as a drug, it will not affect considerably the NO concentration in the system.

KW - Drug

KW - NO

KW - Nitrosation

KW - Radical mechanism

KW - Tetrathiomolybdate

UR - http://www.scopus.com/inward/record.url?scp=77952111740&partnerID=8YFLogxK

U2 - 10.1016/j.inoche.2010.02.010

DO - 10.1016/j.inoche.2010.02.010

M3 - Article

AN - SCOPUS:77952111740

SN - 1387-7003

VL - 13

SP - 589

EP - 592

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

IS - 5

ER -