On the reaction mechanism of MoS42- with nitric oxide

Inna Popivker, Israel Zilbermann, Eric Maimon, Dror Shamir, Naomi Meyerstein, Dan Meyerstein

Research output: Contribution to journalArticlepeer-review

Abstract

MoS42- (TTM) reacts in deaerated neutral phosphate buffered aqueous solutions with NO. Three consecutive reactions are observed. The two first ones obey pseudo first order rate laws with observed rates proportional to [NO]. The third reaction obeys a first order rate law. Nitrite is one of the final products. The mechanism proposed involves thiol nitrosation via a radical mechanism followed by hydrolysis of the S-N bond. The findings indicate that if MoS42- will be used as a drug, it will not affect considerably the NO concentration in the system.

Original languageEnglish
Pages (from-to)589-592
Number of pages4
JournalInorganic Chemistry Communication
Volume13
Issue number5
DOIs
StatePublished - 1 May 2010

Keywords

  • Drug
  • NO
  • Nitrosation
  • Radical mechanism
  • Tetrathiomolybdate

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