On the regulation of acetylcholine release: A study utilizing torpedo synaptosomes and synaptic vesicles

D. M. Michaelson, S. Avissar, I. Ophir, I. Pinchasi, I. Angel, Y. Kloog, M. Sokolovsky

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Addition of ATP to isolated highly purified Torpedo synaptic vesicles results in 45Ca 2+ uptake. Ca 2+ dependent Ach release from Torpedo synaptosomes is accompanied by the phosphorylation of a specific protein with an apparent subunit molecular weight of about 100,000 (band α). 3. Activation of the presynaptic muscarinic receptors by an agonist inhibits Ca 2+-dependent ACh release from Torpedo synaptosomes. This process seems to be mediated through an interference with the phosphorylation of the band α protein, and not by blocking the voltage-dependent presynaptic Ca 2+ channel.

Original languageEnglish
Pages (from-to)505-514
Number of pages10
JournalJournal de Physiologie
Volume76
Issue number5
StatePublished - 31 Dec 1980
Externally publishedYes

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