Addition of ATP to isolated highly purified Torpedo synaptic vesicles results in 45Ca 2+ uptake. Ca 2+ dependent Ach release from Torpedo synaptosomes is accompanied by the phosphorylation of a specific protein with an apparent subunit molecular weight of about 100,000 (band α). 3. Activation of the presynaptic muscarinic receptors by an agonist inhibits Ca 2+-dependent ACh release from Torpedo synaptosomes. This process seems to be mediated through an interference with the phosphorylation of the band α protein, and not by blocking the voltage-dependent presynaptic Ca 2+ channel.
|Number of pages||10|
|Journal||Journal de Physiologie|
|State||Published - 31 Dec 1980|
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