One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells

Vijay B. Kumar, Raj Kumar, Ofir Friedman, Yuval Golan, Aharon Gedanken, Orit Shefi

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Here, we report the use of the chemically modified one-step facile hydrothermal process to develop Boron (B), Nitrogen (N), and Phosphorous (P) doped carbon dots (E@CDs). The chemical characterization of the E@CDs was systematically studied by several analytical techniques that confer doping of elements by known characteristics. The obtained E@CDs had observed very homogeneous size distribution and displayed excitation dependent fluorescence properties, and high quantum yield (QY) was measured in case of B and N doping. Excellent cell viability and good cellular uptake was observed for all E@CDs. Finally, E@CDs were compared with pristine CDs on their effect on cell labelling, neural differentiation process and outgrowth of neurite network. By manipulating the doping of CDs, we can control the branching pattern and outgrowth of neuronal developments. The E@CDs are capable due to their photostability biocompatibility, and possible selective affinity towards nanomedicine applications.

Original languageEnglish
Pages (from-to)4222-4232
Number of pages11
JournalChemistrySelect
Volume4
Issue number14
DOIs
StatePublished - 16 Apr 2019

Keywords

  • Doped carbon dots
  • Fluorescence
  • Hydrothermal process
  • Nanoparticle
  • Neural outgrowth
  • Neural tissue engineering

ASJC Scopus subject areas

  • General Chemistry

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