One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS

Mahesh H. Shinde; Umesh A. Kshirsagar

doi:10.1039/c5gc02771c

One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS

Mahesh H. Shinde, Umesh A. Kshirsagar

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67 Scopus citations

Abstract

Heating of commercially available styrenes with NBS in water followed by reaction with 2-aminopyridines or thioamides afforded important heterocyclic scaffolds in a one pot procedure. The reaction proceeds via co-oxidant free, in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant followed by trapping with suitable nucleophiles to provide imidazopyridines and thiazoles.

Original language	English
Pages (from-to)	1455-1458
Number of pages	4
Journal	Green Chemistry
Volume	18
Issue number	6
DOIs	https://doi.org/10.1039/c5gc02771c
State	Published - 21 Mar 2016
Externally published	Yes

ASJC Scopus subject areas

Environmental Chemistry
Pollution

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abstract = "Heating of commercially available styrenes with NBS in water followed by reaction with 2-aminopyridines or thioamides afforded important heterocyclic scaffolds in a one pot procedure. The reaction proceeds via co-oxidant free, in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant followed by trapping with suitable nucleophiles to provide imidazopyridines and thiazoles.",

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Y1 - 2016/3/21

N2 - Heating of commercially available styrenes with NBS in water followed by reaction with 2-aminopyridines or thioamides afforded important heterocyclic scaffolds in a one pot procedure. The reaction proceeds via co-oxidant free, in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant followed by trapping with suitable nucleophiles to provide imidazopyridines and thiazoles.

AB - Heating of commercially available styrenes with NBS in water followed by reaction with 2-aminopyridines or thioamides afforded important heterocyclic scaffolds in a one pot procedure. The reaction proceeds via co-oxidant free, in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant followed by trapping with suitable nucleophiles to provide imidazopyridines and thiazoles.

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DO - 10.1039/c5gc02771c

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JO - Green Chemistry

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One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS

Abstract

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