One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet; Sara M. Butterfield; Jonas Fuks; Ashraf Brik; Hilal A. Lashuel

doi:10.1039/c3cc45353g

One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet
, Sara M. Butterfield
, Jonas Fuks
, Ashraf Brik
, Hilal A. Lashuel

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Original language	English
Pages (from-to)	9254-9256
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	81
DOIs	https://doi.org/10.1039/c3cc45353g
State	Published - 17 Sep 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc45353g

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title = "One-pot total chemical synthesis of human α-synuclein",

abstract = "Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson{\textquoteright}s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.",

author = "Bruno Fauvet and Butterfield, \{Sara M.\} and Jonas Fuks and Ashraf Brik and Lashuel, \{Hilal A.\}",

year = "2013",

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doi = "10.1039/c3cc45353g",

language = "English",

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T1 - One-pot total chemical synthesis of human α-synuclein

AU - Fauvet, Bruno

AU - Butterfield, Sara M.

AU - Fuks, Jonas

AU - Brik, Ashraf

AU - Lashuel, Hilal A.

PY - 2013/9/17

Y1 - 2013/9/17

N2 - Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

AB - Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

UR - https://www.scopus.com/pages/publications/84884316724

U2 - 10.1039/c3cc45353g

DO - 10.1039/c3cc45353g

M3 - Article

C2 - 23995579

AN - SCOPUS:84884316724

SN - 1359-7345

VL - 49

SP - 9254

EP - 9256

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

One-pot total chemical synthesis of human α-synuclein

Abstract

ASJC Scopus subject areas

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