One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet, Sara M. Butterfield, Jonas Fuks, Ashraf Brik, Hilal A. Lashuel

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Original languageEnglish
Pages (from-to)9254-9256
Number of pages3
JournalChemical Communications
Volume49
Issue number81
DOIs
StatePublished - 17 Sep 2013

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