One stop screening for multiple cancers: The experience of an integrated cancer prevention center

Tal Sella, Ben Boursi, Amira Gat-Charlap, Ilan Aroch, Eliezer Liberman, Menachem Moshkowitz, Ehud Miller, Eyal Gur, Roy Inbar, Arye Blachar, Nicola J. Mabjeesh, Olivia Rosenfeld, Fanny Sperber, Vadim Reiser, Shlomi Kleinman, Ariel J. Jaffa, Miki Bloch, Mati Ormianer, Inna Naumov, Diana KazanovSarah Kraus, Lior Galazan, Nadir Arber

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Cancer is a leading cause of mortality worldwide. Screening is a key strategy for reducing cancer morbidity and mortality. Methods: We aimed to describe the experience of an integrated cancer prevention center in screening an asymptomatic population for the presence of neoplasia. One-thousand consecutive asymptomatic, apparently healthy adults, aged 20-80 years, were screened for early detection of 11 common cancers that account for 70-80% of cancer mortality. Results: Malignant and benign lesions were found in 2.4% and 7.1% of the screenees, respectively. The most common malignant lesions were in the gastrointestinal tract and breast followed by gynecological and skin. The compliance rate for the different screening procedures was considerably higher than the actual screening rate in the general Israeli population - 78% compared to 60% for mammography (p < 0.001) and 39% compared to 16% for colonoscopy (p < 0.001). Advanced age, family history of cancer and certain lifestyle parameters were associated with increased risk. Moreover, polymorphisms in the APC and CD24 genes indicated high cancer risk. When two of the polymorphisms existed in an individual, the risk for a neoplastic lesion was extremely high (OR 2.3 [95% CI 0.94-5.9]). Conclusions: One stop shop screening for 11 common cancers in the setting of a multidisciplinary outpatient clinic is feasible and can detect cancer at an early stage.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume24
Issue number3
DOIs
StatePublished - 1 Apr 2013
Externally publishedYes

Keywords

  • Cancer
  • Early detection
  • Genetic polymorphisms
  • Observational
  • Screening

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