Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II

J. P. Dreier, K. Jurkat-Rott, G. G. Petzold, O. Tomkins, R. Klingebiel, U. A. Kopp, F. Lehmann-Horn, A. Friedman, M. Dichgans

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.

Original languageEnglish
Pages (from-to)2145-2147
Number of pages3
JournalNeurology
Volume64
Issue number12
DOIs
StatePublished - 28 Jun 2005

ASJC Scopus subject areas

  • Clinical Neurology

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