Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II

J. P. Dreier; K. Jurkat-Rott; G. G. Petzold; O. Tomkins; R. Klingebiel; U. A. Kopp; F. Lehmann-Horn; A. Friedman; M. Dichgans

doi:10.1212/01.WNL.0000176298.63840.99

Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II

J. P. Dreier, K. Jurkat-Rott, G. G. Petzold, O. Tomkins, R. Klingebiel, U. A. Kopp, F. Lehmann-Horn, A. Friedman, M. Dichgans

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.

Original language	English
Pages (from-to)	2145-2147
Number of pages	3
Journal	Neurology
Volume	64
Issue number	12
DOIs	https://doi.org/10.1212/01.WNL.0000176298.63840.99
State	Published - 28 Jun 2005

ASJC Scopus subject areas

Clinical Neurology

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abstract = "The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.",

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AU - Dreier, J. P.

AU - Jurkat-Rott, K.

AU - Petzold, G. G.

AU - Tomkins, O.

AU - Klingebiel, R.

AU - Kopp, U. A.

AU - Lehmann-Horn, F.

AU - Friedman, A.

AU - Dichgans, M.

PY - 2005/6/28

Y1 - 2005/6/28

N2 - The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.

AB - The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.

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JO - Neurology

JF - Neurology

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Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II

Abstract

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