Ophthalmic manifestations in Langerhans cell histiocytosis

Jaime Levy, Tova Monos, Joseph Kapelushnik, Esther Maor, Michael Nash, Tova Lifshitz

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Histiocytosis of childhood is characterized by localized or generalized proliferation of cells of the mononuclear phagocyte system and the dendritic cell system. In patients with Langerhans cell histiocytosis, the orbit is the most involved site encountered in ophthalmic practice, usually as a lytic lesion in the zygomaticofrontal suture. Patients usually present with acute or chronic periorbital swelling. Electron microscopic findings of Birbeck granules and positive staining for CD1 antigenic determinant confirm the diagnosis.

Original languageEnglish
Pages (from-to)553-555
Number of pages3
JournalIsrael Medical Association Journal
Issue number9
StatePublished - 1 Sep 2004


  • Langerhans cell histiocytosis
  • Ophthalmic manifestations

ASJC Scopus subject areas

  • General Medicine


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