Optical configuration of pigmented lesion detection by frequency analysis of skin speckle patterns

Yael Bishitz, Nisan Ozana, Ariel Schwarz, Yevgeny Beiderman, Javier Garcia, Zeev Zalevsky

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In this paper we present a novel approach of realizing a safe, simple, and inexpensive sensor applicable to pigmented lesions detection. The approach is based on temporal tracking of back-reflected secondary speckle patterns generated while illuminating the affected area with a laser and applying periodic pressure to the surface via a controlled vibration source. When applied to pigmented lesions, the technique is superior to visual examination in avoiding many false positives and resultant unnecessary biopsies. Applying a series of different vibration frequencies at the examined tissue and analyzing the 2-D time varying speckle patterns in response to the applied periodic pressure creates a unique signature for each and different pigmented lesion. Analyzing these signatures is the first step toward detection of malignant melanoma. In this paper we present preliminary experiments that show the validity of the developed sensor for the classification of pigmented lesions.

Original languageEnglish
Article number253568
Pages (from-to)1003-1014
Number of pages12
JournalBiomedical Optics Express
Issue number3
StatePublished - 24 Feb 2016
Externally publishedYes


  • Medical optics and biotechnology
  • Remote sensing and sensors
  • Speckle

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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