Optical properties of chlorin e6 in living melanoma cells

Antonina I. Dadadzhanova, Ekaterina P. Kolesova, Vladimir G. Maslov, Eliz Amar-Lewis, Riki Goldbart, Tamar Traitel, Joseph Kost, Anna O. Orlova

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The tetrapyrrole chlorin e6 (Ce6) is actively used in photodynamic therapy (PDT) and as a test drug for sonodynamic therapy due to its ability to generate singlet oxygen. In this work, we have analyzed the absorption, photoluminescence (PL), and PL excitation spectra of Ce6 molecules in a nutrient medium and inside the melanoma cells. An analysis of the results shows that Ce6 inside the cancer cells with a low pH remains in monomeric form. A photodynamic test has also been conducted that confirmed the photodynamic effect produced by Ce6 in cancer cells by changing the signals from Ce6 and cells in the absorption and PL spectra.

Original languageEnglish
Title of host publicationBiomedical Spectroscopy, Microscopy, and Imaging
EditorsJurgen Popp, Csilla Gergely
PublisherSPIE
ISBN (Electronic)9781510634909
DOIs
StatePublished - 1 Jan 2020
EventBiomedical Spectroscopy, Microscopy, and Imaging 2020 - Virtual, Online, France
Duration: 6 Apr 202010 Apr 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11359
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceBiomedical Spectroscopy, Microscopy, and Imaging 2020
Country/TerritoryFrance
CityVirtual, Online
Period6/04/2010/04/20

Keywords

  • Aggregation
  • Cancer
  • Chlorin e6
  • Monomers
  • Optical properties
  • Photodynamic therapy
  • Sensitizer
  • Singlet oxygen
  • Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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