Optimal debulking following chemotherapy of advanced‐stage epithelial ovarian carcinoma

Benjamin Piura, Marek Glezerman

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    We reviewed the records of 110 consecutive patients with advanced‐stage epithelial ovarian carcinoma treated at the Soroka Medical Center, Beer‐Sheva, Israel, from 1961‐1987. Twenty patients (18.1%) had optimal debulking at initial laparotomy, 30 patients (27.2%) had nonoptimal debulking at initial laparotomy, 20 patients (18.1%) had an “inoperable” disease at initial laparotomy, and 40 patients (36.3%) had such poorly written records that no information about the degree of resectability at initial laparotomy could be obtained. Four patients, in whom the residual tumor left at initial laparotomy had responded to chemotherapy, had a second laparotomy. In all four patients optimal debulking surgery at second laparotomy was easy to perform and was successful. The value of a second laparotomy after a few cycles of chemotherapy in order to optimally debulk the residual tumor left at initial laparotomy is discussed. It is concluded that a second attempt of debulking surgery after chemotherapy has a respectable place in the management of patients with advanced‐state epithelial ovarian carcinoma, but further research is needed.

    Original languageEnglish
    Pages (from-to)237-240
    Number of pages4
    JournalJournal of Surgical Oncology
    Volume40
    Issue number4
    DOIs
    StatePublished - 1 Jan 1989

    Keywords

    • cisplatinum‐containing combination chemotherapy
    • debulking surgery
    • laparotomy

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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