Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

F. Groppi; M. L. Bonardi; C. Birattari; E. Menapace; K. Abbas; U. Holzwarth; A. Alfarano; S. Morzenti; C. Zona; Z. B. Alfassi

doi:10.1016/j.apradiso.2005.05.041

Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

F. Groppi, M. L. Bonardi, C. Birattari, E. Menapace, K. Abbas, U. Holzwarth, A. Alfarano, S. Morzenti, C. Zona, Z. B. Alfassi

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The production of no-carrier-added (NCA) α-emitter ²¹¹At/^211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the ²⁰⁹Bi(α,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the γ-emitter ²¹⁰At and its long half-lived α-emitting daughter ²¹⁰Po is optimised and minimised by appropriate choice of energy and energy loss of α particle beam. The measured excitation functions for production of the main radioisotopic impurity ²¹⁰At→²¹⁰Po are compared with theoretical predictions from model calculations performed at ENEA.

Original language	English
Pages (from-to)	621-631
Number of pages	11
Journal	Applied Radiation and Isotopes
Volume	63
Issue number	5-6 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.apradiso.2005.05.041
State	Published - 1 Nov 2005

Keywords

High-LET metabolic radiotherapy
NCA At/Po, At/Po, Bi(α, xn) reactions

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2005.05.041

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@article{d9415094671a453d8020e47bd29837dd,

title = "Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes",

abstract = "The production of no-carrier-added (NCA) α-emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(α,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the γ-emitter 210At and its long half-lived α-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of α particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At→210Po are compared with theoretical predictions from model calculations performed at ENEA.",

keywords = "High-LET metabolic radiotherapy, NCA At/Po, At/Po, Bi(α, xn) reactions",

author = "F. Groppi and Bonardi, {M. L.} and C. Birattari and E. Menapace and K. Abbas and U. Holzwarth and A. Alfarano and S. Morzenti and C. Zona and Alfassi, {Z. B.}",

note = "Funding Information: The present research work was funded in the mainframe of the experiment ASTATO of the Commission V of INFN and the MIUR, Italy. The contributions of JRC-Ispra of EC and ENEA-Bologna were substantial.",

year = "2005",

month = nov,

day = "1",

doi = "10.1016/j.apradiso.2005.05.041",

language = "English",

volume = "63",

pages = "621--631",

journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

AU - Groppi, F.

AU - Bonardi, M. L.

AU - Birattari, C.

AU - Menapace, E.

AU - Abbas, K.

AU - Holzwarth, U.

AU - Alfarano, A.

AU - Morzenti, S.

AU - Zona, C.

AU - Alfassi, Z. B.

N1 - Funding Information: The present research work was funded in the mainframe of the experiment ASTATO of the Commission V of INFN and the MIUR, Italy. The contributions of JRC-Ispra of EC and ENEA-Bologna were substantial.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - The production of no-carrier-added (NCA) α-emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(α,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the γ-emitter 210At and its long half-lived α-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of α particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At→210Po are compared with theoretical predictions from model calculations performed at ENEA.

AB - The production of no-carrier-added (NCA) α-emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(α,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the γ-emitter 210At and its long half-lived α-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of α particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At→210Po are compared with theoretical predictions from model calculations performed at ENEA.

KW - High-LET metabolic radiotherapy

KW - NCA At/Po, At/Po, Bi(α, xn) reactions

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U2 - 10.1016/j.apradiso.2005.05.041

DO - 10.1016/j.apradiso.2005.05.041

M3 - Article

C2 - 16055338

AN - SCOPUS:26444435787

SN - 0969-8043

VL - 63

SP - 621

EP - 631

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 5-6 SPEC. ISS.

ER -

Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

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Keywords

ASJC Scopus subject areas

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