Optimization and troubleshooting, limitations, future opportunities for improvement in liposomes drug delivery technologies

K. G. Abishek; Vinod V.T. Padil; Prakash Kumar Sarangi; Garima Gupta; Amirhossein Sahebkar; Umesh Kumar Patil; Prashant Kesharwani; Rambabu Dandela

doi:10.1016/B978-0-443-33548-8.01018-1

Optimization and troubleshooting, limitations, future opportunities for improvement in liposomes drug delivery technologies

K. G. Abishek
, Vinod V.T. Padil
, Prakash Kumar Sarangi
, Garima Gupta
, Amirhossein Sahebkar
, Umesh Kumar Patil
, Prashant Kesharwani
, Rambabu Dandela

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Liposomal drug delivery has emerged as a powerful tool to overcome limitations associated with conventional therapies. These microscopic spheres, mimicking natural cell membranes, offer immense potential for encapsulating and delivering a wide range of therapeutic agents with improved efficacy and reduced side effects. However, challenges remain, including rapid clearance by the reticuloendothelial system (RES) and potential immunogenicity. This chapter explores strategies to optimize liposomal performance, including composition, size, and surface modifications. We discuss methods to troubleshoot common issues encountered during development, such as stability and scalability. Additionally, we examine inherent limitations like RES clearance and drug loading capacity. Looking ahead, this chapter highlights emerging advancements that are expected to revolutionize liposomal drug delivery. Innovations including stimuli-responsive release systems, next-generation targeting ligands, and combination therapy strategies present significant potential for improving targeting precision and therapeutic efficacy.

Original language	English
Title of host publication	Fundamentals and Therapeutic Applications of Liposomes
Publisher	Elsevier
Pages	603-631
Number of pages	29
ISBN (Electronic)	9780443335488
ISBN (Print)	9780443335495
DOIs	https://doi.org/10.1016/B978-0-443-33548-8.01018-1
State	Published - 1 Jan 2025
Externally published	Yes

Keywords

Encapsulation efficiency
Immunogenicity
Liposomal drug delivery
Reticuloendothelial system (RES) clearance
Stability and scalability
Stimuli-responsive liposomes
Surface modification
Targeting ligands
Therapeutic agents

ASJC Scopus subject areas

General Engineering
General Materials Science

Access to Document

10.1016/B978-0-443-33548-8.01018-1

Cite this

Abishek, K. G., Padil, V. V. T., Sarangi, P. K., Gupta, G., Sahebkar, A., Patil, U. K., Kesharwani, P., & Dandela, R. (2025). Optimization and troubleshooting, limitations, future opportunities for improvement in liposomes drug delivery technologies. In Fundamentals and Therapeutic Applications of Liposomes (pp. 603-631). Elsevier. https://doi.org/10.1016/B978-0-443-33548-8.01018-1

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abstract = "Liposomal drug delivery has emerged as a powerful tool to overcome limitations associated with conventional therapies. These microscopic spheres, mimicking natural cell membranes, offer immense potential for encapsulating and delivering a wide range of therapeutic agents with improved efficacy and reduced side effects. However, challenges remain, including rapid clearance by the reticuloendothelial system (RES) and potential immunogenicity. This chapter explores strategies to optimize liposomal performance, including composition, size, and surface modifications. We discuss methods to troubleshoot common issues encountered during development, such as stability and scalability. Additionally, we examine inherent limitations like RES clearance and drug loading capacity. Looking ahead, this chapter highlights emerging advancements that are expected to revolutionize liposomal drug delivery. Innovations including stimuli-responsive release systems, next-generation targeting ligands, and combination therapy strategies present significant potential for improving targeting precision and therapeutic efficacy.",

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AU - Abishek, K. G.

AU - Padil, Vinod V.T.

AU - Sarangi, Prakash Kumar

AU - Gupta, Garima

AU - Sahebkar, Amirhossein

AU - Patil, Umesh Kumar

AU - Kesharwani, Prashant

AU - Dandela, Rambabu

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AB - Liposomal drug delivery has emerged as a powerful tool to overcome limitations associated with conventional therapies. These microscopic spheres, mimicking natural cell membranes, offer immense potential for encapsulating and delivering a wide range of therapeutic agents with improved efficacy and reduced side effects. However, challenges remain, including rapid clearance by the reticuloendothelial system (RES) and potential immunogenicity. This chapter explores strategies to optimize liposomal performance, including composition, size, and surface modifications. We discuss methods to troubleshoot common issues encountered during development, such as stability and scalability. Additionally, we examine inherent limitations like RES clearance and drug loading capacity. Looking ahead, this chapter highlights emerging advancements that are expected to revolutionize liposomal drug delivery. Innovations including stimuli-responsive release systems, next-generation targeting ligands, and combination therapy strategies present significant potential for improving targeting precision and therapeutic efficacy.

KW - Encapsulation efficiency

KW - Immunogenicity

KW - Liposomal drug delivery

KW - Reticuloendothelial system (RES) clearance

KW - Stability and scalability

KW - Stimuli-responsive liposomes

KW - Surface modification

KW - Targeting ligands

KW - Therapeutic agents

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DO - 10.1016/B978-0-443-33548-8.01018-1

M3 - Chapter

AN - SCOPUS:105029206640

SN - 9780443335495

SP - 603

EP - 631

BT - Fundamentals and Therapeutic Applications of Liposomes

PB - Elsevier

ER -

Optimization and troubleshooting, limitations, future opportunities for improvement in liposomes drug delivery technologies

Abstract

Keywords

ASJC Scopus subject areas

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