@article{573c991e7eff4ff1926654f891b610df,
title = "Optimization of transport processes in etched track-based biosensors",
abstract = "A diffusion calculation was performed to simulate the migration kinetics of both analytes and enzymatic reaction products in enzyme-clad nanopores of different sizes and shapes, to estimate the limits of detection, response time and cleaning time of such biosensors, via the maximum possible reaction product enrichment in such pores and the time required for saturation of the corresponding concentration distributions. From this, conclusions concerning the optimum biosensor dimensions are derived.",
keywords = "biotechnology, diffusion, polymers, theory",
author = "Dietmar Fink and Jiri Vacik and Lital Alfonta and Arik Kiv and Yohai Mandabi and {Mu{\~n}oz H.}, G.",
note = "Funding Information: This work was performed within the frame of the guest professorship on the Cathedra Marcos Menzer Mazari at the Universidad Aut{\'o}noma Metropolitana, Iztapalapa, M{\'e}xico City. We are especially obliged to Prof. Salvador Cruz for his everlasting interest in this topic and for numerous valuable discussions. Thanks also to Profs G. Mu{\~n}oz H., J.C. Ter{\'a}n and Mr N. Camarillo for their continuous help and for providing us with adequate working facilities. We also want to acknowledge the very careful and valuable reviewing of the referee which helped improving this work considerably. We also acknowledge the support from the Grant Agency of the Academy of Sciences of the Czech Republic (Research project no. IAA 200480702) for performing some of the examinations at the Nuclear Physics Institute in Rˇ e{\v z}, Czech Republic. Last but not least, we are obliged to Dr P. Apel from JNRI Dubna, Russia for providing us with the ion-irradiated polymer foils.",
year = "2012",
month = aug,
day = "1",
doi = "10.1080/10420150.2011.647914",
language = "English",
volume = "167",
pages = "548--568",
journal = "Radiation Effects and Defects in Solids",
issn = "1042-0150",
publisher = "Taylor and Francis Ltd.",
number = "8",
}