Optimizing Drug Development: Harnessing the Sustainability of Pharmaceutical Cocrystals

Srinivasulu Aitipamula, Geetha Bolla

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Environmental impacts of the industrial revolution necessitate adoption of sustainable practices in all areas of development. The pharmaceutical industry faces increasing pressure to minimize its ecological footprint due to its significant contribution to environmental pollution. Over the past two decades, pharmaceutical cocrystals have received immense popularity due to their ability to optimize the critical attributes of active pharmaceutical ingredients and presented an avenue to bring improved drug products to the market. This review explores the potential of pharmaceutical cocrystals as an ecofriendly alternative to traditional solid forms, offering a sustainable approach to drug development. From reducing the number of required doses to improving the stability of actives, from eliminating synthetic operations to using pharmaceutically approved chemicals, from the use of continuous and solvent-free manufacturing methods to leveraging published data on the safety and toxicology, the cocrystallization approach contributes to sustainability of drug development. The latest trends suggest a promising role of pharmaceutical cocrystals in bringing novel and improved medicines to the market, which has been further fuelled by the recent guidance from the major regulatory agencies.

Original languageEnglish
Pages (from-to)3121-3143
Number of pages23
JournalMolecular Pharmaceutics
Volume21
Issue number7
DOIs
StatePublished - 1 Jul 2024
Externally publishedYes

Keywords

  • cocrystallization
  • crystal engineering
  • drug delivery
  • pharmaceutical cocrystals
  • physicochemical properties
  • sustainability

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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