Oral drug delivery of nanomedicine

Deviprasad Sahoo, Ravi Bandaru, Sangram Keshari Samal, Ramakanta Naik, Pramod Kumar, Prashant Kesharwani, Rambabu Dandela

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

33 Scopus citations

Abstract

Oral drug delivery is the most preferred administration route due to noninvasive, high patient compliance, convenient to handle, and does not require any specific sterile conditions. However, some of the drugs administered orally face several physical, biological, and biochemical barriers which lower the therapeutic efficacy of the drugs before getting absorbed into the systemic circulation. The utilization of nanocarriers for oral drug delivery overcome abovementioned barriers and considered as an alternative strategy to address the drawbacks of oral drug delivery. In this chapter, the recent advancement of nanocarriers in oral drug delivery application for the treatment of various diseases is summarized. Furthermore, the chapter explains how different nanocarriers designing technology enhance the therapeutic potential to overcome the various barriers such as physical, biological, and biochemical. Although, in recent years, several nanocarrier-based drug delivery technologies have been evolved and showing promising results but still it is far from the real utilization in the clinic.

Original languageEnglish
Title of host publicationTheory and Applications of Nonparenteral Nanomedicines
PublisherElsevier
Pages181-207
Number of pages27
ISBN (Electronic)9780128204665
ISBN (Print)9780128204672
DOIs
StatePublished - 1 Jan 2020
Externally publishedYes

Keywords

  • Bioavailability
  • Biological barriers
  • Lipid
  • Nanocarrier
  • Oral drug delivery
  • Polymer

ASJC Scopus subject areas

  • General Economics, Econometrics and Finance
  • General Business, Management and Accounting

Fingerprint

Dive into the research topics of 'Oral drug delivery of nanomedicine'. Together they form a unique fingerprint.

Cite this