Orchestrated efforts on host network hijacking: Processes governing virus replication

Xiaofeng Dai, Olivier Hakizimana, Xuanhao Zhang, Aman Chandra Kaushik, Jianying Zhang

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely “autophagy”, “programmed cell death”, “immune response”, “cell cycle alteration”, and “lipid metabolic reprogramming”, that considerably guide viral replication after host infection in an orchestrated manner. On viral infection, “autophagy” and “programmed cell death” are two dynamically synchronized cell survival programs; “immune response” is a cell defense program typically suppressed by viruses; “cell cycle alteration” and “lipid metabolic reprogramming” are two altered cell housekeeping programs tunable in both directions. We emphasize on their functionalities in modulating viral replication, strategies viruses have evolved to tune these processes for their benefit, and how these processes orchestrate and govern cell fate upon viral infection. Understanding how viruses hijack host networks has both academic and industrial values in providing insights toward therapeutic strategy design for viral disease control, offering useful information in applications that aim to use viral vectors to improve human health such as gene therapy, and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.

Original languageEnglish
Pages (from-to)183-198
Number of pages16
Issue number1
StatePublished - 1 Jan 2020
Externally publishedYes


  • Virus replication
  • autophagy
  • cell cycle alteration
  • immune response
  • lipid metabolic reprogramming
  • programmed cell death

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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