Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials

Mridul Misra, Swaroop Kumar Pandey, Vivek Parashar Pandey, Jyoti Pandey, Renu Tripathi, Rama Pati Tripathi

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

A highly atom economic one pot synthesis of tetrahydropyridines was achieved by l-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 μg/mL.

Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number2
DOIs
StatePublished - 15 Jan 2009
Externally publishedYes

Keywords

  • Antimalarial activity
  • Organocatalysis
  • Schizont maturation
  • Tetrahydropyridines
  • Trifluoroacetic acid
  • l-Proline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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